Josef Lazar, Ph.D.

Laboratory Head

Laboratory of Molecular Neurobiology: Development and applications of genetically encoded probes of cellular processes

Other websites:

Rm. 323, Inst. of Plant Mol. Biology, Branišovská 31, Č. Budějovice
Institute of Nanobiology and Structural Biology GCRC, AS CR, Zámek 136, Nové Hrady

Josef Lazar

Education and positions:

1993 B.Sc., Chemistry, Charles University, Prague, Czech Republic
1996 M.Sc., Organic Chemistry, Charles University / Institute of Organic Chemistry & Biochemistry AS CR, Prague, Czech Republic (laboratory of Miroslav Koutek)
2001 Ph.D., Medicinal Chemistry, University of Utah, Salt Lake City, USA (laboratory of Glenn D. Prestwich)

2002 - 2005 Postdoctoral research fellow, Dept. of Biological Sciences, Columbia University, USA (laboratory of Stuart Firestein)
2006 - 2007 Columbia Science Fellow, Dept. of Biological Sciences, Columbia University, USA (laboratory of Stuart Firestein)

2007 - Head, Laboratory of Cell Biology, Institute of Systems Biology & Ecology, Academy of Sciences of the Czech Republic, Nove Hrady, Czech Republic
2007 - Head, Laboratory of Systems Biology, Institute of Physical Biology, University of South Bohemia, Nove Hrady, Czech Republic
2007 - Head, Laboratory of Molecular Neurobiology, Faculty of Science, University of South Bohemia, Ceske Budejovice, Czech Republic


Awards and Fellowships:

1991, 1995 Academic Scholarship Award, Charles University

2000 University of Utah Graduate Research Fellowship
2001 Don Tucker Memorial Award by the Association for Chemoreception Sciences
2002 R.L. Kirschstein NRSA Fellowship (NIH)
2003 McKnight Technological Innovations in Neuroscience Award, with S. Firestein
2003 Invited lecture, IUPAC meeting, Ottawa, ON, Canada
2006 Columbia Science Fellowship
2007 Special grant in the Chemical Sciences, The Camille & Henry Dreyfus Foundation
2007 Marie Curie Reintegration Grant


Scientific Publications:

Hoskovec M., Koutek B., Lazar J., Streinz L., Brozova E., Kalinova B., Vrkoc J.; a,a-Disubstituted Allyl Sulfones: An Approach to the Synthesis of Vinyl-Branched Pheromone Analogues; Helvetica Chimica Acta 77, 1281-1287, 1994

Koutek B., Hoskovec M., Lazar J.; Estimation of Critical Properties from the Number of Carbon Atoms in Homologous Series; Coll. of Czechoslovak Chem. Commun. 59, 1483-1493, 1994

Plettner E., Lazar J., Prestwich E., Prestwich G.D.; Discrimination of Pheromone Enantiomers by Two Pheromone Binding Proteins from the Gypsy Moth, Lymantria dispar; Biochemistry 39, 8953-62, 2000

Lazar J., Greenwood D.R., Rasmussen L.E.L., Prestwich G.D.; Molecular and Functional Characterization of An Odorant Binding Protein of the Asian Elephant, Elephas maximus: Implications for the role of lipocalins in mammalian olfaction; Biochemistry 41, 11786-94, 2002

Rasmussen L.E.L., Lazar J., Greenwood D.R.; Olfactory Adventures of Elephantine Pheromones. Biochem. Soc. Trans. 31, 137-41, 2003

Lazar J., Rasmussen L.E.L., Greenwood D.R., Bang I.S., Prestwich G.D.; Elephant albumin: a multipurpose pheromone shuttle; Chemistry & Biology, 11(8), 1093-100, 2004

Feng Y., Valley M.T., Lazar J., Yang A.L., Bronson R.T., Firestein S., Coetzee W.A., Manley J.L., SRp38 regulates alternative splicing and is required for Ca(2+) handling in the embryonic heart; Developmental Cell, 2009, 16(4), 528-38

Lazar J., A method for obtaining structural and functional information on proteins, based on polarization fluorescence microscopy, and device implementing said method, patent #302233, Industrial Property Office, Czech Republic, 2010

Lazar J., Bondar A., Timr S., Firestein S.; Two-photon polarization microscopy reveals protein structure and function; Nature Methods, 8, 684-690, 2011